Click the table headers below to sort each column.
| Article | Authors | Journal | Year | Pubmed |
|---|---|---|---|---|
| Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics. | Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. | J Gerontol A Biol Sci Med Sci. | Apr 2012 | Link |
| An epigenetic blockade of cognitive functions in the neurodegenerating brain. | Graff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. | Nature | Feb 2012 | Link |
| Cognitive function in health and disease: the role of epigenetic mechanisms. | Mungenast AE, Tsai LH. | Neurodegener Dis | Feb 2012 | Link |
| Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice. | Siegle JH, Carlen M, Meletis K, Tsai LH, Moore CI, Ritt J. | Conf Proc IEEE Eng Med Biol So | Dec 2011 | Link |
| Disc1 regulates both ?-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. | Gianluca De Rienzo;De Rienzo, G; Bishop, JA; Mao, Y; Pan, L; Ma, TP; Moens, CB; Tsai, LH; Sive, H | FASEB J | Dec 2011 | Link |
| Common DISC1 Polymorphisms Disrupt Wnt/GSK3? Signaling and Brain Development. | Karun K Singh;Singh, KK; De Rienzo, G; Drane, L; Mao, Y; Flood, Z; Madison, J; Ferreira, M; Bergen, S; King, C; Sklar, P; Sive, H; Tsai, LH | Neuron | Nov 2011 | Link |
| Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of ?-secretase (BACE1). | Paola Giusti-Rodr | J Neurosci | Nov 2011 | Link |
| Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. | Jongpil Kim;Kim, J; Su, SC; Wang, H; Cheng, AW; Cassady, JP; Lodato, MA; Lengner, CJ; Chung, CY; Dawlaty, MM; Tsai, LH; Jaenisch, R | Cell Stem Cell | Nov 2011 | Link |
| Cyclin-dependent kinases in brain development and disease. | Susan C Su;Su, SC; Tsai, LH | Annu Rev Cell Dev Biol | Nov 2011 | Link |
| ASPM regulates Wnt signaling pathway activity in the developing brain. | Joshua J Buchman;Buchman, JJ; Durak, O; Tsai, LH | Genes Dev | Sep 2011 | Link |
| Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. | Elaine M Pinheiro;Pinheiro, EM; Xie, Z; Norovich, AL; Vidaki, M; Tsai, LH; Gertler, FB | Nat Cell Biol | Aug 2011 | Link |
| Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. | Stephen J Haggarty;Haggarty, SJ; Tsai, LH | Neurobiol Learn Mem | Jul 2011 | Link |
| Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. | Ji-Song Guan;Guan, JS; Su, SC; Gao, J; Joseph, N; Xie, Z; Zhou, Y; Durak, O; Zhang, L; Zhu, JJ; Clauser, KR; Carr, SA; Tsai, LH | PLoS One | June 2011 | Link |
| Axon selection: From a polarized cytoplasm to a migrating neuron. | Froylan Calderon de Anda;de Anda, FC; Tsai, LH | Commun Integr Biol | May 2011 | Link |
| Epigenetic regulation of gene expression in physiological and pathological brain processes. | Johannes Gr | Physiol Rev | Apr 2011 | Link |
| Cognitive enhancement: A molecular memory booster. | Johannes Gr | Nature | Jan 2011 | Link |
| Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. | Bjoern Schwer;Schwer, B; Schumacher, B; Lombard, DB; Xiao, C; Kurtev, MV; Gao, J; Schneider, JI; Chai, H; Bronson, RT; Tsai, LH; Deng, CX; Alt, FW | Proc Natl Acad Sci U S A | Dec 2010 | Link |
| Targeting the correct HDAC(s) to treat cognitive disorders. | Andr | Trends Pharmacol Sci | Dec 2010 | Link |
| Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. | Sanjay W Pimplikar;Pimplikar, SW; Nixon, RA; Robakis, NK; Shen, J; Tsai, LH | J Neurosci | Nov 2010 | Link |
| Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. | Christopher L Frank;Frank, CL; Ge, X; Xie, Z; Zhou, Y; Tsai, LH | J Biol Chem | Oct 2010 | Link |
| Centrosome motility is essential for initial axon formation in the neocortex. | Froylan Calderon de Anda;de Anda, FC; Meletis, K; Ge, X; Rei, D; Tsai, LH | J Neurosci | Aug 2010 | Link |
| A novel pathway regulates memory and plasticity via SIRT1 and miR-134. | Jun Gao;Gao, J; Wang, WY; Mao, YW; Gr | Nature | Aug 2010 | Link |
| Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. | Karun K Singh;Singh, KK; Ge, X; Mao, Y; Drane, L; Meletis, K; Samuels, BA; Tsai, LH | Neuron | Jul 2010 | Link |
| Negative regulation of Vps34 by Cdk mediated phosphorylation. | Tsuyoshi Furuya;Furuya, T; Kim, M; Lipinski, M; Li, J; Kim, D; Lu, T; Shen, Y; Rameh, L; Yankner, B; Tsai, LH; Yuan, J | Mol Cell | May 2010 | Link |
| Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. | Joshua J Buchman;Buchman, JJ; Tseng, HC; Zhou, Y; Frank, CL; Xie, Z; Tsai, LH | Neuron | May 2010 | Link |
| Guiding neuronal cell migrations. | Oscar Mar | Cold Spring Harb Perspect Biol | Feb 2010 | Link |
| Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. | Xuecai Ge;Ge, X; Frank, CL; Calderon de Anda, F; Tsai, LH | Neuron | Jan 2010 | Link |
| Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. | Jessica A Cardin;Cardin, JA; Carl | Nat Protoc | Jan 2010 | Link |
| MicroTUB(B3)ules and brain development. | Karun K Singh;Singh, KK; Tsai, LH | Cell | Jan 2010 | Link |
| Cyclin-dependent kinases: a family portrait. | Marcos Malumbres;Malumbres, M; Harlow, E; Hunt, T; Hunter, T; Lahti, JM; Manning, G; Morgan, DO; Tsai, LH; Wolgemuth, DJ | Nat Cell Biol | Nov 2009 | Link |
| Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. | David A Davis;Davis, DA; Wilson, MH; Giraud, J; Xie, Z; Tseng, HC; England, C; Herscovitz, H; Tsai, LH; Delalle, I | PLoS Biol | Oct 2009 | Link |
| Linking cell cycle reentry and DNA damage in neurodegeneration. | Dohoon Kim;Kim, D; Tsai, LH | Ann N Y Acad Sci | Jul 2009 | Link |
| Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5. | Lianna R Orlando;Orlando, LR; Ayala, R; Kett, LR; Curley, AA; Duffner, J; Bragg, DC; Tsai, LH; Dunah, AW; Young, AB | J Neurochem | Jul 2009 | Link |
| Bridging physiology and pathology in AD. | Dohoon Kim;Kim, D; Tsai, LH | Cell | Jun 2009 | Link |
| Driving fast-spiking cells induces gamma rhythm and controls sensory responses. | Jessica A Cardin;Cardin, JA; Carl | Nature | Jun 2009 | Link |
| Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. | Christopher L Frank;Frank, CL; Tsai, LH | Neuron | May 2009 | Link |
| HDAC2 negatively regulates memory formation and synaptic plasticity. | Ji-Song Guan;Guan, JS; Haggarty, SJ; Giacometti, E; Dannenberg, JH; Joseph, N; Gao, J; Nieland, TJ; Zhou, Y; Wang, X; Mazitschek, R; Bradner, JE; DePinho, RA; Jaenisch, R; Tsai, LH | Nature | May 2009 | Link |
| Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. | Yingwei Mao;Mao, Y; Ge, X; Frank, CL; Madison, JM; Koehler, AN; Doud, MK; Tassa, C; Berry, EM; Soda, T; Singh, KK; Biechele, T; Petryshen, TL; Moon, RT; Haggarty, SJ; Tsai, LH | Cell | Mar 2009 | Link |
| Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. | Dohoon Kim;Kim, D; Frank, CL; Dobbin, MM; Tsunemoto, RK; Tu, W; Peng, PL; Guan, JS; Lee, BH; Moy, LY; Giusti, P; Broodie, N; Mazitschek, R; Delalle, I; Haggarty, SJ; Neve, RL; Lu, Y; Tsai, LH | Neuron | Dec 2008 | Link |
| Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. | Douglas A Meyer;Meyer, DA; Richer, E; Benkovic, SA; Hayashi, K; Kansy, JW; Hale, CF; Moy, LY; Kim, Y; O'Callaghan, JP; Tsai, LH; Greengard, P; Nairn, AC; Cowan, CW; Miller, DB; Antich, P; Bibb, JA | Proc Natl Acad Sci U S A | Nov 2008 | Link |
| Putting a notch in our understanding of nuclear migration. | Joshua J Buchman;Buchman, JJ; Tsai, LH | Cell | Sep 2008 | Link |
| Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. | Su Yeon Shim;Shim, SY; Samuels, BA; Wang, J; Neumayer, G; Belzil, C; Ayala, R; Shi, Y; Shi, Y; Tsai, LH; Nguyen, MD | J Biol Chem | May 2008 | Link |
| Pyramidal neuron polarity axis is defined at the bipolar stage. | Froylan Calderon de Anda;Calderon de Anda, F; G | J Cell Sci | Jan 2008 | Link |
| Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. | Benjamin Adam Samuels;Samuels, BA; Hsueh, YP; Shu, T; Liang, H; Tseng, HC; Hong, CJ; Su, SC; Volker, J; Neve, RL; Yue, DT; Tsai, LH | Neuron | Dec 2007 | Link |
| Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. | Zhigang Xie;Xie, Z; Moy, LY; Sanada, K; Zhou, Y; Buchman, JJ; Tsai, LH | Neuron | Oct 2007 | Link |
| Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. | Eun-Ah Choe;Choe, EA; Liao, L; Zhou, JY; Cheng, D; Duong, DM; Jin, P; Tsai, LH; Peng, J | J Neurosci | Aug 2007 | Link |
| A hippocampal Cdk5 pathway regulates extinction of contextual fear. | Farahnaz Sananbenesi;Sananbenesi, F; Fischer, A; Wang, X; Schrick, C; Neve, R; Radulovic, J; Tsai, LH | Nat Neurosci | Aug 2007 | Link |
| SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. | Dohoon Kim;Kim, D; Nguyen, MD; Dobbin, MM; Fischer, A; Sananbenesi, F; Rodgers, JT; Delalle, I; Baur, JA; Sui, G; Armour, SM; Puigserver, P; Sinclair, DA; Tsai, LH | EMBO J | Jul 2007 | Link |
| Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord. | Yee Ping Yip;Yip, YP; Capriotti, C; Drill, E; Tsai, LH; Yip, JW | J Comp Neurol | Jul 2007 | Link |
| Recovery of learning and memory is associated with chromatin remodelling. | Andre Fischer;Fischer, A; Sananbenesi, F; Wang, X; Dobbin, M; Tsai, LH | Nature | May 2007 | Link |
| Spindle regulation in neural precursors of flies and mammals. | Joshua J Buchman;Buchman, JJ; Tsai, LH | Nat Rev Neurosci | Feb 2007 | Link |
| Trekking across the brain: the journey of neuronal migration. | Rams | Cell | Jan 2007 | Link |
| p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. | Jonathan C Cruz;Cruz, JC; Kim, D; Moy, LY; Dobbin, MM; Sun, X; Bronson, RT; Tsai, LH | J Neurosci | Oct 2006 | Link |
| Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration. | Zhigang Xie;Xie, Z; Samuels, BA; Tsai, LH | Cereb Cortex | Jul 2006 | Link |
| Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. | Tianzhi Shu;Shu, T; Tseng, HC; Sapir, T; Stern, P; Zhou, Y; Sanada, K; Fischer, A; Coquelle, FM; Reiner, O; Tsai, LH | Neuron | Jan 2006 | Link |
| Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. | Andre Fischer;Fischer, A; Sananbenesi, F; Pang, PT; Lu, B; Tsai, LH | Neuron | Dec 2005 | Link |
| Par-4 links dopamine signaling and depression. | Sang Ki Park;Park, SK; Nguyen, MD; Fischer, A; Luke, MP; Affar, el B; Dieffenbach, PB; Tseng, HC; Shi, Y; Tsai, LH | Cell | Jul 2005 | Link |
| Phosphoproteomic analysis with a solid-phase capture-release-tag approach. | Huang-Chun Tseng;Tseng, HC; Ovaa, H; Wei, NJ; Ploegh, H; Tsai, LH | Chem Biol | Jul 2005 | Link |
| G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. | Kamon Sanada;Sanada, K; Tsai, LH | Cell | Jul 2005 | Link |
| Nucleokinesis in neuronal migration. | Li-Huei Tsai;Tsai, LH; Gleeson, JG | Neuron | May 2005 | Link |
| Mechanism of CDK5/p25 binding by CDK inhibitors. | Marina Mapelli;Mapelli, M; Massimiliano, L; Crovace, C; Seeliger, MA; Tsai, LH; Meijer, L; Musacchio, A | J Med Chem | Feb 2005 | Link |
| Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. | Cataldo Tarricone;Tarricone, C; Perrina, F; Monzani, S; Massimiliano, L; Kim, MH; Derewenda, ZS; Knapp, S; Tsai, LH; Musacchio, A | Neuron | Dec 2004 | Link |
| Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. | Lily Y Moy;Moy, LY; Tsai, LH | J Biol Chem | Dec 2004 | Link |
| Nucleokinesis illuminated. | Benjamin Adam Samuels;Samuels, BA; Tsai, LH | Nat Neurosci | Nov 2004 | Link |
| Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. | Tianzhi Shu;Shu, T; Ayala, R; Nguyen, MD; Xie, Z; Gleeson, JG; Tsai, LH | Neuron | Oct 2004 | Link |
| Cdk5 deregulation in the pathogenesis of Alzheimer's disease. | Jonathan C Cruz;Cruz, JC; Tsai, LH | Trends Mol Med | Sep 2004 | Link |
| A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. | Minh Dang Nguyen;Nguyen, MD; Shu, T; Sanada, K; Larivi | Nat Cell Biol | Jul 2004 | Link |
| A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. | Jonathan C Cruz;Cruz, JC; Tsai, LH | Curr Opin Neurobiol | Jun 2004 | Link |
| Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. | Kamon Sanada;Sanada, K; Gupta, A; Tsai, LH | Neuron | Apr 2004 | Link |
| Cdk5, a therapeutic target for Alzheimer's disease? | Li-Huei Tsai;Tsai, LH; Lee, MS; Cruz, J | Biochim Biophys Acta | Mar 2004 | Link |
| Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. | Uwe Beffert;Beffert, U; Weeber, EJ; Morfini, G; Ko, J; Brady, ST; Tsai, LH; Sweatt, JD; Herz, J | J Neurosci | Feb 2004 | Link |
| Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration. | Zhigang Xie;Xie, Z; Tsai, LH | Cell Cycle | Feb 2004 | Link |
| Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. | Maria A Morabito;Morabito, MA; Sheng, M; Tsai, LH | J Neurosci | Jan 2004 | Link |
| Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. | Teruyuki Tanaka;Tanaka, T; Serneo, FF; Tseng, HC; Kulkarni, AB; Tsai, LH; Gleeson, JG | Neuron | Jan 2004 | Link |
| Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. | Vicki Hammond;Hammond, V; Tsai, LH; Tan, SS | J Neurosci | Jan 2004 | Link |
| BACE1 suppression by RNA interference in primary cortical neurons. | Shih-Chu Kao;Kao, SC; Krichevsky, AM; Kosik, KS; Tsai, LH | J Biol Chem | Jan 2004 | Link |
| Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. | Amitabh Gupta;Gupta, A; Sanada, K; Miyamoto, DT; Rovelstad, S; Nadarajah, B; Pearlman, AL; Brunstrom, J; Tsai, LH | Nat Neurosci | Dec 2003 | Link |
| Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. | Jonathan C Cruz;Cruz, JC; Tseng, HC; Goldman, JA; Shih, H; Tsai, LH | Neuron | Oct 2003 | Link |
| APP processing is regulated by cytoplasmic phosphorylation. | Ming-Sum Lee;Lee, MS; Kao, SC; Lemere, CA; Xia, W; Tseng, HC; Zhou, Y; Neve, R; Ahlijanian, MK; Tsai, LH | J Cell Biol | Oct 2003 | Link |
| Cyclin-dependent kinase 5 and neuronal migration in the neocortex. | Amitabh Gupta;Gupta, A; Tsai, LH | Neurosignals | Sep 2003 | Link |
| Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. | Zhigang Xie;Xie, Z; Sanada, K; Samuels, BA; Shih, H; Tsai, LH | Cell | Aug 2003 | Link |
| Cdk5 is a dynamo at the synapse. | Benjamin Adam Samuels;Samuels, BA; Tsai, LH | Nat Cell Biol | Aug 2003 | Link |
| 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. | Kazuhito Toyo-oka;Toyo-oka, K; Shionoya, A; Gambello, MJ; Cardoso, C; Leventer, R; Ward, HL; Ayala, R; Tsai, LH; Dobyns, W; Ledbetter, D; Hirotsune, S; Wynshaw-Boris, A | Nat Genet | Jul 2003 | Link |
| Cdk5: one of the links between senile plaques and neurofibrillary tangles? | Ming-Sum Lee;Lee, MS; Tsai, LH | J Alzheimers Dis | Apr 2003 | Link |
| Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. | Holger Patzke;Patzke, H; Maddineni, U; Ayala, R; Morabito, M; Volker, J; Dikkes, P; Ahlijanian, MK; Tsai, LH | J Neurosci | Apr 2003 | Link |
| The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. | Rani Dhavan;Dhavan, R; Greer, PL; Morabito, MA; Orlando, LR; Tsai, LH | J Neurosci | Sep 2002 | Link |
| A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. | Huang Chun Tseng;Tseng, HC; Zhou, Y; Shen, Y; Tsai, LH | FEBS Lett | Jul 2002 | Link |
| Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. | Jean C Augustinack;Augustinack, JC; Sanders, JL; Tsai, LH; Hyman, BT | J Neuropathol Exp Neurol | Jun 2002 | Link |
| Life is a journey: a genetic look at neocortical development. | Amitabh Gupta;Gupta, A; Tsai, LH; Wynshaw-Boris, A | Nat Rev Genet | May 2002 | Link |
| Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. | Holger Patzke;Patzke, H; Tsai, LH | J Biol Chem | Mar 2002 | Link |
| GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. | Sarah Ross;Ross, S; Tienhaara, A; Lee, MS; Tsai, LH; Gill, G | J Biol Chem | Feb 2002 | Link |
| Cdk5 behind the wheel: a role in trafficking and transport? | Deanna S Smith;Smith, DS; Tsai, LH | Trends Cell Biol | Jan 2002 | Link |
| Cdk5 sinks into ALS. | Holger Patzke;Patzke, H; Tsai, LH | Trends Neurosci | Jan 2002 | Link |